Publication: Validation and application of a liquid chromatographic-mass spectrometric method for determination of artesunate in pharmaceutical samples
| dc.contributor.author | N. Lindegårdh | en_US |
| dc.contributor.author | A. M. Dondorp | en_US |
| dc.contributor.author | P. Singhasivanon | en_US |
| dc.contributor.author | N. J. White | en_US |
| dc.contributor.author | N. P J Day | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | Nuffield Department of Clinical Medicine | en_US |
| dc.date.accessioned | 2018-08-24T01:45:49Z | |
| dc.date.available | 2018-08-24T01:45:49Z | |
| dc.date.issued | 2007-09-21 | en_US |
| dc.description.abstract | A simple and rapid liquid chromatographic-mass spectrometric assay for the evaluation of artesunate in vials for injection has been developed and validated. The content of each vial was dissolved in 3.0 mL of methanol using a SGE analytical syringe (1.0 mL). Each sample was diluted to a theoretical concentration of 1000 ng/mL and analysed in triplicate. Three replicates of calibration standards at concentrations 500, 1000 and 1500 ng/mL were used to construct a calibration curve. Artesunate was analysed by liquid chromatography with atmospheric pressure chemical ionisation (APCI) mass spectrometric (MS) detection on a Hypersil Gold column (100 mm × 4.6 mm) using a mobile phase containing methanol-ammonium acetate 10 mM pH 5.3 (70:30, v/v) at a flow rate of 1 mL/min. The assay was implemented for the analysis of artesunate for injection purchased from Guilin Pharmaceutical Company in China. © 2007 Elsevier B.V. All rights reserved. | en_US |
| dc.identifier.citation | Journal of Pharmaceutical and Biomedical Analysis. Vol.45, No.1 (2007), 149-153 | en_US |
| dc.identifier.doi | 10.1016/j.jpba.2007.04.030 | en_US |
| dc.identifier.issn | 07317085 | en_US |
| dc.identifier.other | 2-s2.0-34548474579 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/24336 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34548474579&origin=inward | en_US |
| dc.subject | Chemistry | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | Validation and application of a liquid chromatographic-mass spectrometric method for determination of artesunate in pharmaceutical samples | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34548474579&origin=inward | en_US |