Publication: A rhodamine-triazole fluorescent chemodosimeter for Cu<sup>2+</sup> detection and its application in bioimaging
Issued Date
2018-02-01
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ISSN
15227243
15227235
15227235
DOI
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2-s2.0-85024100001
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Mahidol University
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SCOPUS
Bibliographic Citation
Luminescence. Vol.33, No.1 (2018), 64-70
Suggested Citation
Kanokorn Wechakorn, Samran Prabpai, Kanoknetr Suksen, Phongthon Kanjanasirirat, Yongyut Pewkliang, Suparerk Borwornpinyo, Palangpon Kongsaeree A rhodamine-triazole fluorescent chemodosimeter for Cu<sup>2+</sup> detection and its application in bioimaging. Luminescence. Vol.33, No.1 (2018), 64-70. doi:10.1002/bio.3373 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/45250
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Title
A rhodamine-triazole fluorescent chemodosimeter for Cu<sup>2+</sup> detection and its application in bioimaging
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Abstract
Copyright © 2017 John Wiley & Sons, Ltd. A rhodamine-based fluorescent chemodosimeter rhodamine hydrazide-triazole (RHT) tethered with a triazole moiety was developed for Cu2+ detection. In aqueous medium, the RHT probe exhibited high selectivity and sensitivity toward Cu2+ among other metal ions. The addition of Cu2+ triggered a fluorescence emission of RHT by 384-fold (Φ = 0.33) based on a ring-opening process and a subsequent hydrolysis reaction. Moreover, RHT also showed a selective colorimetric response toward Cu2+ from colorless solution to pink, readily observed with the naked eye. The limit of detection of RHT for Cu2+ was calculated to be 1 nM (0.06 ppb). RHT was successfully demonstrated to detect Cu2+ in Chang liver cells by confocal fluorescence microscopy.