Publication:
Synthesis of racemic and optically active forms of novel antimalarial agents, spirocyclopentanone-anthracene adducts, via tandem Michael addition-Dieckmann condensation reactions as the key steps

Issued Date

2012-03-15

Resource Type

Article

ISSN

1362511X
09574166

DOI

10.1016/j.tetasy.2012.03.006

Other identifier(s)

2-s2.0-84860307253

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Tetrahedron Asymmetry. Vol.23, No.5 (2012), 357-363

Suggested Citation

Ruangrat Choommongkol, Rattana Jongkol, Samran Prabpai, Palangpon Kongsaeree, Puttinan Meepowpan Synthesis of racemic and optically active forms of novel antimalarial agents, spirocyclopentanone-anthracene adducts, via tandem Michael addition-Dieckmann condensation reactions as the key steps. Tetrahedron Asymmetry. Vol.23, No.5 (2012), 357-363. doi:10.1016/j.tetasy.2012.03.006 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/13922

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Title

Synthesis of racemic and optically active forms of novel antimalarial agents, spirocyclopentanone-anthracene adducts, via tandem Michael addition-Dieckmann condensation reactions as the key steps

Author(s)

Ruangrat Choommongkol
 Rattana Jongkol
 Samran Prabpai
 Palangpon Kongsaeree
 Puttinan Meepowpan

Other Contributor(s)

Chiang Mai University
 Mahidol University

Abstract

Spirocyclopentanone-anthracene adducts, novel antimalarial agents, have been synthesized by employing the racemic and the optically active dimethyl itaconate-anthracene adducts in a reaction with piperine via tandem Michael addition-Dieckmann condensation reactions as the key steps. All adducts exhibited antimalarial activity with IC 50 values of 3.4-4.7 μg/mL, and importantly displayed non-cytotoxicity to vero cells. © 2012 Elsevier Ltd. All rights reserved.

Keyword(s)

Chemical Engineering
 Chemistry

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/13922

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Scopus 2011-2015