Publication: Synthesis of racemic and optically active forms of novel antimalarial agents, spirocyclopentanone-anthracene adducts, via tandem Michael addition-Dieckmann condensation reactions as the key steps
| dc.contributor.author | Ruangrat Choommongkol | en_US |
| dc.contributor.author | Rattana Jongkol | en_US |
| dc.contributor.author | Samran Prabpai | en_US |
| dc.contributor.author | Palangpon Kongsaeree | en_US |
| dc.contributor.author | Puttinan Meepowpan | en_US |
| dc.contributor.other | Chiang Mai University | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.date.accessioned | 2018-06-11T04:41:50Z | |
| dc.date.available | 2018-06-11T04:41:50Z | |
| dc.date.issued | 2012-03-15 | en_US |
| dc.description.abstract | Spirocyclopentanone-anthracene adducts, novel antimalarial agents, have been synthesized by employing the racemic and the optically active dimethyl itaconate-anthracene adducts in a reaction with piperine via tandem Michael addition-Dieckmann condensation reactions as the key steps. All adducts exhibited antimalarial activity with IC 50 values of 3.4-4.7 μg/mL, and importantly displayed non-cytotoxicity to vero cells. © 2012 Elsevier Ltd. All rights reserved. | en_US |
| dc.identifier.citation | Tetrahedron Asymmetry. Vol.23, No.5 (2012), 357-363 | en_US |
| dc.identifier.doi | 10.1016/j.tetasy.2012.03.006 | en_US |
| dc.identifier.issn | 1362511X | en_US |
| dc.identifier.issn | 09574166 | en_US |
| dc.identifier.other | 2-s2.0-84860307253 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/13922 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84860307253&origin=inward | en_US |
| dc.subject | Chemical Engineering | en_US |
| dc.subject | Chemistry | en_US |
| dc.title | Synthesis of racemic and optically active forms of novel antimalarial agents, spirocyclopentanone-anthracene adducts, via tandem Michael addition-Dieckmann condensation reactions as the key steps | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84860307253&origin=inward | en_US |