Publication: Inhibition of intestinal glucose absorption in several animal species by cytochalasins
Issued Date
1980-12-01
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ISSN
00345164
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2-s2.0-0019179003
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Mahidol University
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SCOPUS
Bibliographic Citation
Research Communications in Chemical Pathology and Pharmacology. Vol.30, No.3 (1980), 521-534
Suggested Citation
C. Toskulkao, T. Glinsukon, B. Kongsuktrakoon, S. Sophasan, W. Thamavit Inhibition of intestinal glucose absorption in several animal species by cytochalasins. Research Communications in Chemical Pathology and Pharmacology. Vol.30, No.3 (1980), 521-534. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/11186
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Title
Inhibition of intestinal glucose absorption in several animal species by cytochalasins
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Abstract
The effect of various cytochalasins on intestinal glucose absorption in several animal species was investigated in vitro. Glucose absorption in mouse jejunum was highly inhibited (68.1%) by cytochalasin E (25.0 μg/ml) within 30-min incubation and less extent in rat (48.9%), hamster (34.1%), frog (28.1%), guinea pig (27.5%), rabbit (24.3%) and turtle jejunum (22.7%). Among cytochalasins A, B, C, D and E, cytochalasin E was a most potent derivative that could inhibit glucose absorption by up to 55.5% at a concentration of only 5.0 μg/ml in mouse jejunum and its effect may possibly be related to the formation of mini villi and the intracellular vacuoles in the intestinal absorptive cells.