Publication: Antiviral and antiplasmodial spirodihydrobenzofuran terpenes from the fungus Stachybotrys nephrospora
Issued Date
2004-11-01
Resource Type
ISSN
00320943
Other identifier(s)
2-s2.0-9744238022
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Planta Medica. Vol.70, No.11 (2004), 1085-1087
Suggested Citation
Supaporn Sawadjoon, Prasat Kittakoop, Masahiko Isaka, Kanyawim Kirtikara, Siribhorn Madla, Yodhathai Thebtaranonth Antiviral and antiplasmodial spirodihydrobenzofuran terpenes from the fungus Stachybotrys nephrospora. Planta Medica. Vol.70, No.11 (2004), 1085-1087. doi:10.1055/s-2004-832652 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/21136
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Antiviral and antiplasmodial spirodihydrobenzofuran terpenes from the fungus Stachybotrys nephrospora
Other Contributor(s)
Abstract
Two known spirodihydrobenzofuran terpenes (1 and 2) were isolated from a mycelium extract of the fungus Stachybotrys nephrospora BCC 3900. Compound 1 (Mer-NF5003F or stachybotrydial) exhibited potent antiviral activity (the IC50 value of 4.32 μg/mL) comparable to the standard drug, acyclovir, while compound 2 was inactive against the HSV-1 virus. Both 1 and 2 possessed antiplasmodial activity (IC50 values of 0.85 and 0.15 μg/mL for 1 and 2, respectively), and were not toxic towards the Vero cell line. A regiospecific conversion of the dialdehyde 1 to the lactone 2 proceeded simply under acidic conditions.