Publication: Antiviral and antiplasmodial spirodihydrobenzofuran terpenes from the fungus Stachybotrys nephrospora
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2004-11-01
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00320943
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2-s2.0-9744238022
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Mahidol University
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SCOPUS
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Planta Medica. Vol.70, No.11 (2004), 1085-1087
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Supaporn Sawadjoon, Prasat Kittakoop, Masahiko Isaka, Kanyawim Kirtikara, Siribhorn Madla, Yodhathai Thebtaranonth Antiviral and antiplasmodial spirodihydrobenzofuran terpenes from the fungus Stachybotrys nephrospora. Planta Medica. Vol.70, No.11 (2004), 1085-1087. doi:10.1055/s-2004-832652 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/21136
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Antiviral and antiplasmodial spirodihydrobenzofuran terpenes from the fungus Stachybotrys nephrospora
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Two known spirodihydrobenzofuran terpenes (1 and 2) were isolated from a mycelium extract of the fungus Stachybotrys nephrospora BCC 3900. Compound 1 (Mer-NF5003F or stachybotrydial) exhibited potent antiviral activity (the IC50 value of 4.32 μg/mL) comparable to the standard drug, acyclovir, while compound 2 was inactive against the HSV-1 virus. Both 1 and 2 possessed antiplasmodial activity (IC50 values of 0.85 and 0.15 μg/mL for 1 and 2, respectively), and were not toxic towards the Vero cell line. A regiospecific conversion of the dialdehyde 1 to the lactone 2 proceeded simply under acidic conditions.