Publication: Antiviral and antiplasmodial spirodihydrobenzofuran terpenes from the fungus Stachybotrys nephrospora
| dc.contributor.author | Supaporn Sawadjoon | en_US |
| dc.contributor.author | Prasat Kittakoop | en_US |
| dc.contributor.author | Masahiko Isaka | en_US |
| dc.contributor.author | Kanyawim Kirtikara | en_US |
| dc.contributor.author | Siribhorn Madla | en_US |
| dc.contributor.author | Yodhathai Thebtaranonth | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | Thailand National Center for Genetic Engineering and Biotechnology | en_US |
| dc.date.accessioned | 2018-07-24T03:36:16Z | |
| dc.date.available | 2018-07-24T03:36:16Z | |
| dc.date.issued | 2004-11-01 | en_US |
| dc.description.abstract | Two known spirodihydrobenzofuran terpenes (1 and 2) were isolated from a mycelium extract of the fungus Stachybotrys nephrospora BCC 3900. Compound 1 (Mer-NF5003F or stachybotrydial) exhibited potent antiviral activity (the IC50 value of 4.32 μg/mL) comparable to the standard drug, acyclovir, while compound 2 was inactive against the HSV-1 virus. Both 1 and 2 possessed antiplasmodial activity (IC50 values of 0.85 and 0.15 μg/mL for 1 and 2, respectively), and were not toxic towards the Vero cell line. A regiospecific conversion of the dialdehyde 1 to the lactone 2 proceeded simply under acidic conditions. | en_US |
| dc.identifier.citation | Planta Medica. Vol.70, No.11 (2004), 1085-1087 | en_US |
| dc.identifier.doi | 10.1055/s-2004-832652 | en_US |
| dc.identifier.issn | 00320943 | en_US |
| dc.identifier.other | 2-s2.0-9744238022 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/21136 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=9744238022&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.subject | Chemistry | en_US |
| dc.subject | Medicine | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | Antiviral and antiplasmodial spirodihydrobenzofuran terpenes from the fungus Stachybotrys nephrospora | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=9744238022&origin=inward | en_US |