Publication: Role of maternal humoral immunity in vertical transmission of HIV-1 subtype E in Thailand
Issued Date
1999-08-01
Resource Type
ISSN
10779450
Other identifier(s)
2-s2.0-0033178840
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. Vol.21, No.4 (1999), 259-265
Suggested Citation
S. Louisirirotchanakul, S. Beddows, R. Cheingsong, N. Shaffer, T. D. Mastro, S. Likanonsakul, C. Wasi, G. P. Taylor, J. N. Weber Role of maternal humoral immunity in vertical transmission of HIV-1 subtype E in Thailand. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. Vol.21, No.4 (1999), 259-265. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/25438
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Role of maternal humoral immunity in vertical transmission of HIV-1 subtype E in Thailand
Abstract
The significance of the maternal humoral immune response in relation to vertical transmission of HIV-1 was investigated in 123 mothers infected with subtype E from Thailand. Antibody binding titers to HIV-1 env domains (monomeric gp120, the CD4/gp120 binding site [BS], V3 loop, and gp41) and antibody-mediated neutralization of primary and T-cell line-adapted (TCLA) subtypes B and E HIV-1 isolates were investigated. No correlation between maternal anti HIV-1 antibodies at delivery and vertical transmission of HIV- 1 subtype E was found. However, a trend to higher titer antibody-mediated cross-neutralization of a heterologous subtype B TCLA isolate, HIV-1(MN), was observed in nontransmitting mothers postpartum. The HIV-1-specific antibody titers in these infected mothers increased significantly from delivery to 6 months postpartum (p < .05), but this was only partially attributable to hemodilution and an additional factor or factors appear to affect humoral immunity to HIV-1 during late pregnancy.