Publication:
Role of maternal humoral immunity in vertical transmission of HIV-1 subtype E in Thailand

Simple item page
dc.contributor.authorS. Louisirirotchanakulen_US
dc.contributor.authorS. Beddowsen_US
dc.contributor.authorR. Cheingsongen_US
dc.contributor.authorN. Shafferen_US
dc.contributor.authorT. D. Mastroen_US
dc.contributor.authorS. Likanonsakulen_US
dc.contributor.authorC. Wasien_US
dc.contributor.authorG. P. Tayloren_US
dc.contributor.authorJ. N. Weberen_US
dc.contributor.otherImperial College Londonen_US
dc.contributor.otherHIV/AIDS Collaborationen_US
dc.contributor.otherCenters for Disease Control and Preventionen_US
dc.contributor.otherBamrasnaradura Infectious Disease Instituteen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-09-07T08:50:51Z
dc.date.available2018-09-07T08:50:51Z
dc.date.issued1999-08-01en_US
dc.description.abstractThe significance of the maternal humoral immune response in relation to vertical transmission of HIV-1 was investigated in 123 mothers infected with subtype E from Thailand. Antibody binding titers to HIV-1 env domains (monomeric gp120, the CD4/gp120 binding site [BS], V3 loop, and gp41) and antibody-mediated neutralization of primary and T-cell line-adapted (TCLA) subtypes B and E HIV-1 isolates were investigated. No correlation between maternal anti HIV-1 antibodies at delivery and vertical transmission of HIV- 1 subtype E was found. However, a trend to higher titer antibody-mediated cross-neutralization of a heterologous subtype B TCLA isolate, HIV-1(MN), was observed in nontransmitting mothers postpartum. The HIV-1-specific antibody titers in these infected mothers increased significantly from delivery to 6 months postpartum (p < .05), but this was only partially attributable to hemodilution and an additional factor or factors appear to affect humoral immunity to HIV-1 during late pregnancy.en_US
dc.identifier.citationJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology. Vol.21, No.4 (1999), 259-265en_US
dc.identifier.issn10779450en_US
dc.identifier.other2-s2.0-0033178840en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/25438
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0033178840&origin=inwarden_US
dc.subjectImmunology and Microbiologyen_US
dc.subjectMedicineen_US
dc.titleRole of maternal humoral immunity in vertical transmission of HIV-1 subtype E in Thailanden_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0033178840&origin=inwarden_US

Files

Collections

Scopus 1991-2000