Publication: Cystargamide B, a cyclic lipodepsipeptide with protease inhibitory activity from Streptomyces sp.
2
Issued Date
2018-07-01
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ISSN
18811469
00218820
00218820
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2-s2.0-85044324946
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Antibiotics. Vol.71, No.7 (2018), 662-666
Suggested Citation
Shigeru Kitani, Mitsuki Yoshida, Ousana Boonlucksanawong, Watanalai Panbangred, Atchareeya Anuegoonpipat, Takeshi Kurosu, Kazuyoshi Ikuta, Yasuhiro Igarashi, Takuya Nihira Cystargamide B, a cyclic lipodepsipeptide with protease inhibitory activity from Streptomyces sp.. Journal of Antibiotics. Vol.71, No.7 (2018), 662-666. doi:10.1038/s41429-018-0044-0 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/47309
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Title
Cystargamide B, a cyclic lipodepsipeptide with protease inhibitory activity from Streptomyces sp.
Abstract
© 2018 The Author(s) under exclusive licence to the Japan Antibiotics Research Association. We identified a new cyclic lipodepsipeptide, cystargamide B (1), from the mycelial extract of a Kaempferia galanga rhizome-derived actinomycete strain, Streptomyces sp. PB013. The planar structure was elucidated based on high resolution fast-atom bombardment mass spectrometry (HRFABMS) spectroscopy and one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopic data. The absolute configurations of the constituent amino acids were determined using advanced Marfey's method. Cystargamide B (1) includes rare structural units: a 5-hydroxytryptophan residue and a 2,3-epoxy fatty acid side chain. Notably, cystargamide B (1) inhibited the protease activity of the NS2B/NS3 complex from dengue virus.