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Cystargamide B, a cyclic lipodepsipeptide with protease inhibitory activity from Streptomyces sp.

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dc.contributor.authorShigeru Kitanien_US
dc.contributor.authorMitsuki Yoshidaen_US
dc.contributor.authorOusana Boonlucksanawongen_US
dc.contributor.authorWatanalai Panbangreden_US
dc.contributor.authorAtchareeya Anuegoonpipaten_US
dc.contributor.authorTakeshi Kurosuen_US
dc.contributor.authorKazuyoshi Ikutaen_US
dc.contributor.authorYasuhiro Igarashien_US
dc.contributor.authorTakuya Nihiraen_US
dc.contributor.otherToyama Prefectural Universityen_US
dc.contributor.otherNational Institute of Infectious Diseasesen_US
dc.contributor.otherOsaka Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNational Institutes of Health, Bethesdaen_US
dc.date.accessioned2019-08-28T06:50:13Z
dc.date.available2019-08-28T06:50:13Z
dc.date.issued2018-07-01en_US
dc.description.abstract© 2018 The Author(s) under exclusive licence to the Japan Antibiotics Research Association. We identified a new cyclic lipodepsipeptide, cystargamide B (1), from the mycelial extract of a Kaempferia galanga rhizome-derived actinomycete strain, Streptomyces sp. PB013. The planar structure was elucidated based on high resolution fast-atom bombardment mass spectrometry (HRFABMS) spectroscopy and one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopic data. The absolute configurations of the constituent amino acids were determined using advanced Marfey's method. Cystargamide B (1) includes rare structural units: a 5-hydroxytryptophan residue and a 2,3-epoxy fatty acid side chain. Notably, cystargamide B (1) inhibited the protease activity of the NS2B/NS3 complex from dengue virus.en_US
dc.identifier.citationJournal of Antibiotics. Vol.71, No.7 (2018), 662-666en_US
dc.identifier.doi10.1038/s41429-018-0044-0en_US
dc.identifier.issn18811469en_US
dc.identifier.issn00218820en_US
dc.identifier.other2-s2.0-85044324946en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/47309
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85044324946&origin=inwarden_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleCystargamide B, a cyclic lipodepsipeptide with protease inhibitory activity from Streptomyces sp.en_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85044324946&origin=inwarden_US

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