Publication: High-performance liquid chromatographic determination of dihydroorotate dehydrogenase of Plasmodium falciparum and effects of antimalarials on enzyme activity
| dc.contributor.author | Isra Ittarat | en_US |
| dc.contributor.author | H. Kyle Webster | en_US |
| dc.contributor.author | Yongyuth Yuthavong | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | Armed Forces Research Institute of Medical Sciences, Thailand | en_US |
| dc.date.accessioned | 2018-08-10T08:44:10Z | |
| dc.date.available | 2018-08-10T08:44:10Z | |
| dc.date.issued | 1992-11-06 | en_US |
| dc.description.abstract | A reversed-phase high-performance liquid chromatographic technique for the determination of dihydroorotate dehydrogenase in Plasmodium falciparum was developed. The assay was applied to the evaluation of the effects of several antimalarial drugs on the enzyme. Treatment of both the asexual and gametocyte stages of P. falciparum in culture with menoctone, primaquine or the primaquine derivative WR 238605 led to depression of the enzyme activity, although the drugs did not appear to inhibit the enzyme directly. © 1992. | en_US |
| dc.identifier.citation | Journal of Chromatography B: Biomedical Sciences and Applications. Vol.582, No.1-2 (1992), 57-64 | en_US |
| dc.identifier.doi | 10.1016/0378-4347(92)80302-7 | en_US |
| dc.identifier.issn | 03784347 | en_US |
| dc.identifier.other | 2-s2.0-0026455012 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/22252 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0026455012&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.subject | Chemistry | en_US |
| dc.title | High-performance liquid chromatographic determination of dihydroorotate dehydrogenase of Plasmodium falciparum and effects of antimalarials on enzyme activity | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0026455012&origin=inward | en_US |