Publication: Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys
Issued Date
2018-06-01
Resource Type
ISSN
1546170X
10788956
10788956
Other identifier(s)
2-s2.0-85048016859
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Mahidol University
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SCOPUS
Bibliographic Citation
Nature Medicine. Vol.24, No.6 (2018), 721-723
Suggested Citation
Peter Abbink, Rafael A. Larocca, Wanwisa Dejnirattisai, Rebecca Peterson, Joseph P. Nkolola, Erica N. Borducchi, Piyada Supasa, Juthathip Mongkolsapaya, Gavin R. Screaton, Dan H. Barouch Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys. Nature Medicine. Vol.24, No.6 (2018), 721-723. doi:10.1038/s41591-018-0056-0 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/45157
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Title
Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys
Abstract
© 2018 The Author(s). Strategies to treat Zika virus (ZIKV) infection in dengue virus (DENV)-endemic areas are urgently needed. Here we show that a DENV-specific antibody against the E-dimer epitope (EDE) potently cross-neutralizes ZIKV and provides robust therapeutic efficacy as well as prophylactic efficacy against ZIKV in rhesus monkeys. Viral escape was not detected, suggesting a relatively high bar to escape. These data demonstrate the potential for antibody-based therapy and prevention of ZIKV.