Publication: Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys
| dc.contributor.author | Peter Abbink | en_US |
| dc.contributor.author | Rafael A. Larocca | en_US |
| dc.contributor.author | Wanwisa Dejnirattisai | en_US |
| dc.contributor.author | Rebecca Peterson | en_US |
| dc.contributor.author | Joseph P. Nkolola | en_US |
| dc.contributor.author | Erica N. Borducchi | en_US |
| dc.contributor.author | Piyada Supasa | en_US |
| dc.contributor.author | Juthathip Mongkolsapaya | en_US |
| dc.contributor.author | Gavin R. Screaton | en_US |
| dc.contributor.author | Dan H. Barouch | en_US |
| dc.contributor.other | University of Oxford | en_US |
| dc.contributor.other | Massachusetts Institute of Technology | en_US |
| dc.contributor.other | Imperial College London | en_US |
| dc.contributor.other | Faculty of Medicine, Siriraj Hospital, Mahidol University | en_US |
| dc.contributor.other | Harvard Medical School | en_US |
| dc.date.accessioned | 2019-08-23T10:33:13Z | |
| dc.date.available | 2019-08-23T10:33:13Z | |
| dc.date.issued | 2018-06-01 | en_US |
| dc.description.abstract | © 2018 The Author(s). Strategies to treat Zika virus (ZIKV) infection in dengue virus (DENV)-endemic areas are urgently needed. Here we show that a DENV-specific antibody against the E-dimer epitope (EDE) potently cross-neutralizes ZIKV and provides robust therapeutic efficacy as well as prophylactic efficacy against ZIKV in rhesus monkeys. Viral escape was not detected, suggesting a relatively high bar to escape. These data demonstrate the potential for antibody-based therapy and prevention of ZIKV. | en_US |
| dc.identifier.citation | Nature Medicine. Vol.24, No.6 (2018), 721-723 | en_US |
| dc.identifier.doi | 10.1038/s41591-018-0056-0 | en_US |
| dc.identifier.issn | 1546170X | en_US |
| dc.identifier.issn | 10788956 | en_US |
| dc.identifier.other | 2-s2.0-85048016859 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/45157 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85048016859&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.title | Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85048016859&origin=inward | en_US |