Publication: 11-Hydroxymonocerin from the plant endophytic fungus Exserohilum rostratum
Issued Date
2008-09-01
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ISSN
01633864
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2-s2.0-54149106109
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Natural Products. Vol.71, No.9 (2008), 1657-1659
Suggested Citation
Ruengrit Sappapan, Damrong Sommit, Nattaya Ngamrojanavanich, Somchai Pengpreecha, Suthep Wiyakrutta, Nongluksna Sriubolmas, Khanitha Pudhom 11-Hydroxymonocerin from the plant endophytic fungus Exserohilum rostratum. Journal of Natural Products. Vol.71, No.9 (2008), 1657-1659. doi:10.1021/np8004024 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/18870
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Title
11-Hydroxymonocerin from the plant endophytic fungus Exserohilum rostratum
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Abstract
A new analogue of monocerin, 11-hydroxymonocerin (2), along with monocerin (1) and 12-hydroxymonocerin (3) were isolated from cultures of Exserohilum rostratum, a fungal strain endophytic in Stemona sp. The structure of 2 was determined by analysis of NMR and MS data and by comparison of spectroscopic data to those of 1. Monocerin (1) and 11-hydroxymonocerin (2) displayed activity against Plasmodium falciparum (K1, multidrug-resistant strain) with IC 50 values of 0.68 and 7.70 μM, respectively. None of the compounds were cytotoxic against any of the tumor cell lines tested. © 2008 American Chemical Society and American Society of Pharmacognosy.