Publication:
Crossed immunoelectrophoresis for the detection of split products of the third complement component in dengue hemorrhagic fever. II. In vitro activation by dengue viral antigen

3

Issued Date

1984-01-01

Resource Type

Article

ISSN

00029637

DOI

10.4269/ajtmh.1984.33.1239

Other identifier(s)

2-s2.0-0021716314

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

American Journal of Tropical Medicine and Hygiene. Vol.33, No.6 (1984), 1239-1247

Suggested Citation

V. Churdboonchart, N. Bhamarapravati, S. Yoksan Crossed immunoelectrophoresis for the detection of split products of the third complement component in dengue hemorrhagic fever. II. In vitro activation by dengue viral antigen. American Journal of Tropical Medicine and Hygiene. Vol.33, No.6 (1984), 1239-1247. doi:10.4269/ajtmh.1984.33.1239 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/30613

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Title

Crossed immunoelectrophoresis for the detection of split products of the third complement component in dengue hemorrhagic fever. II. In vitro activation by dengue viral antigen

Author(s)

V. Churdboonchart
 N. Bhamarapravati
 S. Yoksan

Other Contributor(s)

Mahidol University

Abstract

The ability of dengue viral antigen(s) from different sources, and preformed antigen-antibody complexes, to activate the third component of human complement (C3) in vitro was demonstrated by using split products of human C3. Dengue type 2 viral antigen(s) from suckling mouse brain and from infected monocytes activated C3 via the alternative pathway, while preformed soluble dengue-2 antibody complex activated mainly the classical pathway. The implications of this finding for the pathogenesis of dengue hemorrhagic fever are discussed.

Keyword(s)

Immunology and Microbiology
 Medicine

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https://repository.li.mahidol.ac.th/handle/123456789/30613

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Scopus 1969-1990