Publication: Maternal and viral factors in vertical transmission of HIV-1 subtype E
Issued Date
1997-12-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-0031301530
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.28, No.4 (1997), 689-698
Suggested Citation
Ruengpung Sutthent, Suporn Foongladda, Sanay Chearskul, Niran Wanaprapa, Sirirat Likanonskul, Uraiwan Kositanont, Suda Riengrojpitak, Somphong Sahapong, Chantapong Wasi Maternal and viral factors in vertical transmission of HIV-1 subtype E. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.28, No.4 (1997), 689-698. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/18046
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Title
Maternal and viral factors in vertical transmission of HIV-1 subtype E
Abstract
Vertical transmission of HIV-1 is caused by multifactorial factors. To access the relationship of viral factors involving in perinatal transmission of HIV-1 subtype E, which is the predominant type in Thailand, plasma viral load, blood CD4+ lymphocyte level, heteroduplex mobility, and V3 sequence of the HIV-1 envelope gene were studied in 32 transmitting and 25 non-transmitting mothers. We found that HIV-1 subtype E vertical transmission was strongly associated with high maternal plasma viral RNA (> 4 × 104 copies/ml) and high genetic diversity of envelope gene determined by heteroduplex mobility (< 0.9). The variation of nucleotide sequences in envelope gene of subtype E vertical transmission could not determine in V3 region. Hence, plasma viral load and heteroduplex mobility can be used as prediction factors in vertical transmission of HIV-1 subtype E.