Publication:
Unexpected enhancement in biological activity of a GPCR ligand induced by an oligoethylene glycol substituent

Issued Date

2010-07-07

Resource Type

Article

ISSN

15205126
00027863

DOI

10.1021/ja102640c

Other identifier(s)

2-s2.0-77954301795

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of the American Chemical Society. Vol.132, No.26 (2010), 8844-8845

Suggested Citation

Chutima Jiarpinitnun, Laura L. Kiessling Unexpected enhancement in biological activity of a GPCR ligand induced by an oligoethylene glycol substituent. Journal of the American Chemical Society. Vol.132, No.26 (2010), 8844-8845. doi:10.1021/ja102640c Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/28671

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Title

Unexpected enhancement in biological activity of a GPCR ligand induced by an oligoethylene glycol substituent

Author(s)

Chutima Jiarpinitnun
 Laura L. Kiessling

Other Contributor(s)

University of Wisconsin Madison
 Mahidol University

Abstract

Polyethylene glycol (PEG) is widely used, and many biologically active molecules are modified with oligoethylene glycol substituents to enhance their half-lives in circulation. The pervasive use of PEG substituents is partly due to their presumed inertness. Our investigation of formyl peptide receptor (FPR)-mediated chemotaxis reveals that oligoethylene glycol substitution can enhance the ability of the peptide chemoattractant N-formyl-methionine-leucine- phenylalanine (fMLF) to activate signal transduction through FPR, a transmembrane G-protein-coupled receptor. © 2010 American Chemical Society.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Chemical Engineering
 Chemistry
 Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/28671

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Scopus 2006-2010