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Unexpected enhancement in biological activity of a GPCR ligand induced by an oligoethylene glycol substituent

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dc.contributor.authorChutima Jiarpinitnunen_US
dc.contributor.authorLaura L. Kiesslingen_US
dc.contributor.otherUniversity of Wisconsin Madisonen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-09-24T08:43:56Z
dc.date.available2018-09-24T08:43:56Z
dc.date.issued2010-07-07en_US
dc.description.abstractPolyethylene glycol (PEG) is widely used, and many biologically active molecules are modified with oligoethylene glycol substituents to enhance their half-lives in circulation. The pervasive use of PEG substituents is partly due to their presumed inertness. Our investigation of formyl peptide receptor (FPR)-mediated chemotaxis reveals that oligoethylene glycol substitution can enhance the ability of the peptide chemoattractant N-formyl-methionine-leucine- phenylalanine (fMLF) to activate signal transduction through FPR, a transmembrane G-protein-coupled receptor. © 2010 American Chemical Society.en_US
dc.identifier.citationJournal of the American Chemical Society. Vol.132, No.26 (2010), 8844-8845en_US
dc.identifier.doi10.1021/ja102640cen_US
dc.identifier.issn15205126en_US
dc.identifier.issn00027863en_US
dc.identifier.other2-s2.0-77954301795en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/28671
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77954301795&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectChemical Engineeringen_US
dc.subjectChemistryen_US
dc.subjectMedicineen_US
dc.titleUnexpected enhancement in biological activity of a GPCR ligand induced by an oligoethylene glycol substituenten_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77954301795&origin=inwarden_US

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