Publication: Comparative accuracy of the InBios scrub typhus detect IgM rapid test for the detection of IgM antibodies by using conventional serology
Issued Date
2015-10-01
Resource Type
ISSN
1556679X
15566811
15566811
Other identifier(s)
2-s2.0-84943262734
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Mahidol University
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SCOPUS
Bibliographic Citation
Clinical and Vaccine Immunology. Vol.22, No.10 (2015), 1130-1132
Suggested Citation
Hugh W.F. Kingston, Stuart D. Blacksell, Ampai Tanganuchitcharnchai, Achara Laongnualpanich, Buddha Basnyat, Nicholas P.J. Day, Daniel H. Paris Comparative accuracy of the InBios scrub typhus detect IgM rapid test for the detection of IgM antibodies by using conventional serology. Clinical and Vaccine Immunology. Vol.22, No.10 (2015), 1130-1132. doi:10.1128/CVI.00390-15 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/35377
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Title
Comparative accuracy of the InBios scrub typhus detect IgM rapid test for the detection of IgM antibodies by using conventional serology
Abstract
Copyright © 2015, American Society for Microbiology. All Rights Reserved. This study investigated the comparative accuracy of a recombinant 56-kDa type-specific antigen-based rapid diagnostic test (RDT) for scrub typhus for the detection of IgM antibodies by using conventional serology in well-characterized serum samples from undifferentiated febrile illness patients. The RDT showed high specificity and promising comparative accuracy, with 82% sensitivity and 98% specificity for samples defined positive at an IgM indirect immunofluorescence assay positivity cutoff titer of ≥1:1,600 versus 92% and 95% at ≥1:6,400, respectively.