Publication:
Influence of pr-M cleavage on the heterogeneity of extracellular dengue virus particles

Simple item page
dc.contributor.authorJiraphan Junjhonen_US
dc.contributor.authorThomas J. Edwardsen_US
dc.contributor.authorUtaiwan Utaipaten_US
dc.contributor.authorValorie D. Bowmanen_US
dc.contributor.authorHeather A. Holdawayen_US
dc.contributor.authorWei Zhangen_US
dc.contributor.authorPoonsook Keelapangen_US
dc.contributor.authorChunya Puttikhunten_US
dc.contributor.authorRushika Pereraen_US
dc.contributor.authorPaul R. Chipmanen_US
dc.contributor.authorWatchara Kasinrerken_US
dc.contributor.authorPrida Malasiten_US
dc.contributor.authorRichard J. Kuhnen_US
dc.contributor.authorNopporn Sittisombuten_US
dc.contributor.otherChiang Mai Universityen_US
dc.contributor.otherPurdue Universityen_US
dc.contributor.otherThailand National Center for Genetic Engineering and Biotechnologyen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-09-24T09:05:03Z
dc.date.available2018-09-24T09:05:03Z
dc.date.issued2010-08-01en_US
dc.description.abstractDuring dengue virus replication, an incomplete cleavage of the envelope glycoprotein prM, generates a mixture of mature (prM-less) and prM-containing, immature extracellular particles. In this study, sequential immunoprecipitation and cryoelectron microscopy revealed a third type of extracellular particles, the partially mature particles, as the major prM-containing particles in a dengue serotype 2 virus. Changes in the proportion of viral particles in the pr-M junction mutants exhibiting altered levels of prM cleavage suggest that the partially mature particles may represent an intermediate subpopulation in the virus maturation pathway. These findings are consistent with a model suggesting the progressive mode of prM cleavage. Copyright © 2010, American Society for Microbiology. All Rights Reserved.en_US
dc.identifier.citationJournal of Virology. Vol.84, No.16 (2010), 8253-8358en_US
dc.identifier.doi10.1128/JVI.00696-10en_US
dc.identifier.issn10985514en_US
dc.identifier.issn0022538Xen_US
dc.identifier.other2-s2.0-77954972691en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/29207
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77954972691&origin=inwarden_US
dc.subjectImmunology and Microbiologyen_US
dc.titleInfluence of pr-M cleavage on the heterogeneity of extracellular dengue virus particlesen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77954972691&origin=inwarden_US

Files

Collections

Scopus 2006-2010