Publication: Long-term outcomes of chronic hepatitis C patients with sustained virological response at 6 months after the end of treatment
Issued Date
2006-09-14
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ISSN
10079327
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2-s2.0-33749413206
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Mahidol University
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SCOPUS
Bibliographic Citation
World Journal of Gastroenterology. Vol.12, No.34 (2006), 5532-5535
Suggested Citation
Disaya Chavalitdhamrong, Tawesak Tanwandee Long-term outcomes of chronic hepatitis C patients with sustained virological response at 6 months after the end of treatment. World Journal of Gastroenterology. Vol.12, No.34 (2006), 5532-5535. doi:10.3748/wjg.v12.i34.5532 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23615
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Title
Long-term outcomes of chronic hepatitis C patients with sustained virological response at 6 months after the end of treatment
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Abstract
Aim: To assess the clinical, biochemical, and virological outcome during long-term follow-up of chronic hepatitis C patients with sustained virological response following effective antiviral therapy. Methods: This study was a retrospective cohort study including 171 sustained responders defined as HCV RNA PCR negative at 6 mo after the end of effective antiviral treatment (SVR-6). Clinical signs and symptoms, biochemical hepatic parameters, ultrasonography and HCV RNA PCR were followed. Results: Mean follow-up period was 35.38 ± 22.2 mo after the end of treatment. Twenty-seven (15.8%) responders had evidence of cirrhosis before treatment. Forty-eight (28.1%), 107 (62.6%) and 6 (3.5%) patients were genotype 1, 3, and 6 respectively, while 10 patients (5.8%) were unclassified. There were no virological and biochemical relapses during the period of follow-up. None of the patients showed evidence of hepatic decompensation. However, there were 3 patients (1.8%) developing hepatocellular carcinoma at 14, 18, 29 mo after treatment discontinuation, two of whom had evidence of cirrhosis prior to therapy. Conclusion: The study shows that during a follow-up interval for about 3 years in 171 chronic hepatitis C patients with sustained viral response after effective antiviral treatment there were no evident signs of either biochemical or clinical relapse of liver disease in all but three patients who developed hepatocellular carcinoma. © 2006 The WJG Press. All rights reserved.