Publication:
Long-term outcomes of chronic hepatitis C patients with sustained virological response at 6 months after the end of treatment

dc.contributor.authorDisaya Chavalitdhamrongen_US
dc.contributor.authorTawesak Tanwandeeen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-08-20T07:11:56Z
dc.date.available2018-08-20T07:11:56Z
dc.date.issued2006-09-14en_US
dc.description.abstractAim: To assess the clinical, biochemical, and virological outcome during long-term follow-up of chronic hepatitis C patients with sustained virological response following effective antiviral therapy. Methods: This study was a retrospective cohort study including 171 sustained responders defined as HCV RNA PCR negative at 6 mo after the end of effective antiviral treatment (SVR-6). Clinical signs and symptoms, biochemical hepatic parameters, ultrasonography and HCV RNA PCR were followed. Results: Mean follow-up period was 35.38 ± 22.2 mo after the end of treatment. Twenty-seven (15.8%) responders had evidence of cirrhosis before treatment. Forty-eight (28.1%), 107 (62.6%) and 6 (3.5%) patients were genotype 1, 3, and 6 respectively, while 10 patients (5.8%) were unclassified. There were no virological and biochemical relapses during the period of follow-up. None of the patients showed evidence of hepatic decompensation. However, there were 3 patients (1.8%) developing hepatocellular carcinoma at 14, 18, 29 mo after treatment discontinuation, two of whom had evidence of cirrhosis prior to therapy. Conclusion: The study shows that during a follow-up interval for about 3 years in 171 chronic hepatitis C patients with sustained viral response after effective antiviral treatment there were no evident signs of either biochemical or clinical relapse of liver disease in all but three patients who developed hepatocellular carcinoma. © 2006 The WJG Press. All rights reserved.en_US
dc.identifier.citationWorld Journal of Gastroenterology. Vol.12, No.34 (2006), 5532-5535en_US
dc.identifier.doi10.3748/wjg.v12.i34.5532en_US
dc.identifier.issn10079327en_US
dc.identifier.other2-s2.0-33749413206en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/23615
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33749413206&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleLong-term outcomes of chronic hepatitis C patients with sustained virological response at 6 months after the end of treatmenten_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33749413206&origin=inwarden_US

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