Publication: Linking dengue virus entry and translation/replication through amphisomes
Issued Date
2009-04-01
Resource Type
ISSN
15548635
15548627
15548627
Other identifier(s)
2-s2.0-65249100786
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Autophagy. Vol.5, No.3 (2009), 434-435
Suggested Citation
Mingkwan Panyasrivanit, Atefeh Khakpoor, Nitwara Wikan, Duncan R. Smith Linking dengue virus entry and translation/replication through amphisomes. Autophagy. Vol.5, No.3 (2009), 434-435. doi:10.4161/auto.5.3.7925 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/27249
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Linking dengue virus entry and translation/replication through amphisomes
Other Contributor(s)
Abstract
Amphisomes are preautolysosomal vacuoles formed upon the fusion of autophagosomes with endosomes, and as such represent a critical meeting point between endocytic and autophagic pathways. Dengue virus enters into susceptible cells by clathrin-mediated endocytosis, and colocalization of dengue markers with markers of both autophagic and endosomal vesicles demonstrates that amphi-somes are a site of dengue virus replication and translation. This work links for the first time the processes of dengue virus entry and translation/replication, and allows for interpretation of the early part of the dengue virus life cycle in terms of a continual association with membranes of an endosomal-autophagosomal lineage. © 2009 Landes Bioscience.