Publication: Review of the evidence regarding the use of antenatal multiple micronutrient supplementation in low- and middle-income countries
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Issued Date
2019-05-01
Resource Type
ISSN
17496632
00778923
00778923
Other identifier(s)
2-s2.0-85066409444
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Mahidol University
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SCOPUS
Bibliographic Citation
Annals of the New York Academy of Sciences. Vol.1444, No.1 (2019), 6-21
Suggested Citation
Megan W. Bourassa, Saskia J.M. Osendarp, Seth Adu-Afarwuah, Saima Ahmed, Clayton Ajello, Gilles Bergeron, Robert Black, Parul Christian, Simon Cousens, Saskia de Pee, Kathryn G. Dewey, Shams El Arifeen, Reina Engle-Stone, Alison Fleet, Alison D. Gernand, John Hoddinott, Rolf Klemm, Klaus Kraemer, Roland Kupka, Erin McLean, Sophie E. Moore, Lynnette M. Neufeld, Lars Åke Persson, Kathleen M. Rasmussen, Anuraj H. Shankar, Emily Smith, Christopher R. Sudfeld, Emorn Udomkesmalee, Stephen A. Vosti Review of the evidence regarding the use of antenatal multiple micronutrient supplementation in low- and middle-income countries. Annals of the New York Academy of Sciences. Vol.1444, No.1 (2019), 6-21. doi:10.1111/nyas.14121 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/49950
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Title
Review of the evidence regarding the use of antenatal multiple micronutrient supplementation in low- and middle-income countries
Author(s)
Megan W. Bourassa
Saskia J.M. Osendarp
Seth Adu-Afarwuah
Saima Ahmed
Clayton Ajello
Gilles Bergeron
Robert Black
Parul Christian
Simon Cousens
Saskia de Pee
Kathryn G. Dewey
Shams El Arifeen
Reina Engle-Stone
Alison Fleet
Alison D. Gernand
John Hoddinott
Rolf Klemm
Klaus Kraemer
Roland Kupka
Erin McLean
Sophie E. Moore
Lynnette M. Neufeld
Lars Åke Persson
Kathleen M. Rasmussen
Anuraj H. Shankar
Emily Smith
Christopher R. Sudfeld
Emorn Udomkesmalee
Stephen A. Vosti
Saskia J.M. Osendarp
Seth Adu-Afarwuah
Saima Ahmed
Clayton Ajello
Gilles Bergeron
Robert Black
Parul Christian
Simon Cousens
Saskia de Pee
Kathryn G. Dewey
Shams El Arifeen
Reina Engle-Stone
Alison Fleet
Alison D. Gernand
John Hoddinott
Rolf Klemm
Klaus Kraemer
Roland Kupka
Erin McLean
Sophie E. Moore
Lynnette M. Neufeld
Lars Åke Persson
Kathleen M. Rasmussen
Anuraj H. Shankar
Emily Smith
Christopher R. Sudfeld
Emorn Udomkesmalee
Stephen A. Vosti
Other Contributor(s)
Global Alliance for Improved Nutrition
World Food Program, Italy
Harvard T.H. Chan School of Public Health
London School of Hygiene & Tropical Medicine
New York Academy of Sciences
Tufts University
Bill and Melinda Gates Foundation
University of Ghana
University of California, Davis
Mahidol University
King's College London
International Centre for Diarrhoeal Disease Research Bangladesh
UNICEF
Cornell University
Johns Hopkins Bloomberg School of Public Health
Wageningen University and Research Centre
Pennsylvania State University
The Vitamin Angels Alliance, Inc.
Helen Keller International
London School of Hygiene and Tropical Medicine
Osendarp Nutrition
Summit Institute of Development
Sight and Life
World Food Program, Italy
Harvard T.H. Chan School of Public Health
London School of Hygiene & Tropical Medicine
New York Academy of Sciences
Tufts University
Bill and Melinda Gates Foundation
University of Ghana
University of California, Davis
Mahidol University
King's College London
International Centre for Diarrhoeal Disease Research Bangladesh
UNICEF
Cornell University
Johns Hopkins Bloomberg School of Public Health
Wageningen University and Research Centre
Pennsylvania State University
The Vitamin Angels Alliance, Inc.
Helen Keller International
London School of Hygiene and Tropical Medicine
Osendarp Nutrition
Summit Institute of Development
Sight and Life
Abstract
© 2019 The Authors. Annals of the New York Academy of Sciences published by Wiley Periodicals, Inc. on behalf of New York Academy of Sciences. Inadequate micronutrient intakes are relatively common in low- and middle-income countries (LMICs), especially among pregnant women, who have increased micronutrient requirements. This can lead to an increase in adverse pregnancy and birth outcomes. This review presents the conclusions of a task force that set out to assess the prevalence of inadequate micronutrient intakes and adverse birth outcomes in LMICs; the data from trials comparing multiple micronutrient supplements (MMS) that contain iron and folic acid (IFA) with IFA supplements alone; the risks of reaching the upper intake levels with MMS; and the cost-effectiveness of MMS compared with IFA. Recent meta-analyses demonstrate that MMS can reduce the risks of preterm birth, low birth weight, and small for gestational age in comparison with IFA alone. An individual-participant data meta-analysis also revealed even greater benefits for anemic and underweight women and female infants. Importantly, there was no increased risk of harm for the pregnant women or their infants with MMS. These data suggest that countries with inadequate micronutrient intakes should consider supplementing pregnant women with MMS as a cost-effective method to reduce the risk of adverse birth outcomes.