Publication: Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers
1
Issued Date
2012-12-15
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ISSN
14643405
0960894X
0960894X
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2-s2.0-84870236110
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Mahidol University
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SCOPUS
Bibliographic Citation
Bioorganic and Medicinal Chemistry Letters. Vol.22, No.24 (2012), 7598-7601
Suggested Citation
Supannee Phothongkam, Sirirat Chancharunee, Angkana Saovapakhiran, Uthai Wichai, Manat Pohmakotr Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers. Bioorganic and Medicinal Chemistry Letters. Vol.22, No.24 (2012), 7598-7601. doi:10.1016/j.bmcl.2012.10.020 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/13546
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Title
Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers
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Abstract
In this research, N-(2-aminoethyl)glycine-linked C-10 non-acetal deoxoartemisinin dimers were synthesized by using solution phase peptide synthesis approach. In addition, chemical modification of the C-10 non-acetal deoxoartemisinin monomers and dimers by adding a lysine unit to the N-terminus has been performed. The biological activities of all synthesized compounds were evaluated against the colon cancer cell line (Caco-2). The non-acetal deoxoartemisinin monomers 12a, 15a-c and dime rs 13a, 16a-c were active against Caco-2 cells and more potent than dihydroartemisinin. © 2012 Elsevier Ltd. All rights reserved.