Publication: Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers
| dc.contributor.author | Supannee Phothongkam | en_US |
| dc.contributor.author | Sirirat Chancharunee | en_US |
| dc.contributor.author | Angkana Saovapakhiran | en_US |
| dc.contributor.author | Uthai Wichai | en_US |
| dc.contributor.author | Manat Pohmakotr | en_US |
| dc.contributor.other | Chiang Mai University | en_US |
| dc.contributor.other | Naresuan University | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.date.accessioned | 2018-06-11T04:32:24Z | |
| dc.date.available | 2018-06-11T04:32:24Z | |
| dc.date.issued | 2012-12-15 | en_US |
| dc.description.abstract | In this research, N-(2-aminoethyl)glycine-linked C-10 non-acetal deoxoartemisinin dimers were synthesized by using solution phase peptide synthesis approach. In addition, chemical modification of the C-10 non-acetal deoxoartemisinin monomers and dimers by adding a lysine unit to the N-terminus has been performed. The biological activities of all synthesized compounds were evaluated against the colon cancer cell line (Caco-2). The non-acetal deoxoartemisinin monomers 12a, 15a-c and dime rs 13a, 16a-c were active against Caco-2 cells and more potent than dihydroartemisinin. © 2012 Elsevier Ltd. All rights reserved. | en_US |
| dc.identifier.citation | Bioorganic and Medicinal Chemistry Letters. Vol.22, No.24 (2012), 7598-7601 | en_US |
| dc.identifier.doi | 10.1016/j.bmcl.2012.10.020 | en_US |
| dc.identifier.issn | 14643405 | en_US |
| dc.identifier.issn | 0960894X | en_US |
| dc.identifier.other | 2-s2.0-84870236110 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/123456789/13546 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84870236110&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.subject | Chemistry | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | Facile synthesis and anticancer activity of C-10 non-acetal deoxoartemisinin dimers | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84870236110&origin=inward | en_US |