Publication: Berberine, a natural isoquinoline alkaloid, induces NAG-1 and ATF3 expression in human colorectal cancer cells
Issued Date
2007-12-18
Resource Type
ISSN
03043835
Other identifier(s)
2-s2.0-36148962372
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Cancer Letters. Vol.258, No.2 (2007), 230-240
Suggested Citation
Rojsanga Piyanuch, Mugdha Sukhthankar, Gritsanapan Wandee, Seung Joon Baek Berberine, a natural isoquinoline alkaloid, induces NAG-1 and ATF3 expression in human colorectal cancer cells. Cancer Letters. Vol.258, No.2 (2007), 230-240. doi:10.1016/j.canlet.2007.09.007 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24058
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Berberine, a natural isoquinoline alkaloid, induces NAG-1 and ATF3 expression in human colorectal cancer cells
Other Contributor(s)
Abstract
Berberine is known to possess a wide variety of pharmacological activities, including pro-apoptotic activity. However, its molecular targets are not elucidated at present. NAG-1 and ATF3 are induced by several dietary compounds associated with pro-apoptotic activity. Berberine induces cell growth arrest, apoptosis, NAG-1, and ATF3 in human colorectal cancer cells. ATF3 induction by berberine is mediated in a p53-dependent manner, whereas NAG-1 induction by berberine is mediated by multiple signaling pathways. Our results suggest that berberine facilitates apoptosis and that NAG-1 and ATF3 expression plays an important role in berberine-induced apoptosis. © 2007 Elsevier Ireland Ltd. All rights reserved.