Publication: Berberine, a natural isoquinoline alkaloid, induces NAG-1 and ATF3 expression in human colorectal cancer cells
| dc.contributor.author | Rojsanga Piyanuch | en_US |
| dc.contributor.author | Mugdha Sukhthankar | en_US |
| dc.contributor.author | Gritsanapan Wandee | en_US |
| dc.contributor.author | Seung Joon Baek | en_US |
| dc.contributor.other | University of Tennessee College of Veterinary Medicine | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.date.accessioned | 2018-08-24T01:39:12Z | |
| dc.date.available | 2018-08-24T01:39:12Z | |
| dc.date.issued | 2007-12-18 | en_US |
| dc.description.abstract | Berberine is known to possess a wide variety of pharmacological activities, including pro-apoptotic activity. However, its molecular targets are not elucidated at present. NAG-1 and ATF3 are induced by several dietary compounds associated with pro-apoptotic activity. Berberine induces cell growth arrest, apoptosis, NAG-1, and ATF3 in human colorectal cancer cells. ATF3 induction by berberine is mediated in a p53-dependent manner, whereas NAG-1 induction by berberine is mediated by multiple signaling pathways. Our results suggest that berberine facilitates apoptosis and that NAG-1 and ATF3 expression plays an important role in berberine-induced apoptosis. © 2007 Elsevier Ireland Ltd. All rights reserved. | en_US |
| dc.identifier.citation | Cancer Letters. Vol.258, No.2 (2007), 230-240 | en_US |
| dc.identifier.doi | 10.1016/j.canlet.2007.09.007 | en_US |
| dc.identifier.issn | 03043835 | en_US |
| dc.identifier.other | 2-s2.0-36148962372 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/24058 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=36148962372&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.subject | Medicine | en_US |
| dc.title | Berberine, a natural isoquinoline alkaloid, induces NAG-1 and ATF3 expression in human colorectal cancer cells | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=36148962372&origin=inward | en_US |