Publication: Boesenmaxane Diterpenoids from Boesenbergia maxwellii
Issued Date
2021-02-26
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ISSN
15206025
01633864
01633864
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2-s2.0-85099089779
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Natural Products. Vol.84, No.2 (2021), 518-526
Suggested Citation
The S. Moe, Suppisak Chaturonrutsamee, Samreang Bunteang, Chutima Kuhakarn, Samran Prabpai, Panida Surawatanawong, Arthit Chairoungdua, Kanoknetr Suksen, Radeekorn Akkarawongsapat, Jitra Limthongkul, Chanita Napaswad, Narong Nuntasaen, Vichai Reutrakul Boesenmaxane Diterpenoids from Boesenbergia maxwellii. Journal of Natural Products. Vol.84, No.2 (2021), 518-526. doi:10.1021/acs.jnatprod.0c00629 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/76275
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Title
Boesenmaxane Diterpenoids from Boesenbergia maxwellii
Abstract
Three new diterpenoids, boesenmaxanes A-C (1-3), with an unprecedented core skeleton consisting of an unusual C-C bond between C-12 and an exo-cyclic methylene C-13, were isolated from the rhizome extracts of Boesenbergia maxwellii. The structures were elucidated by analysis of spectroscopic and X-ray diffraction data. Electronic circular dichroism spectra were used to determine the absolute configuration. All the isolates were evaluated for their cytotoxic effects, anti-HIV activity, and antimicrobial activity. Boesenmaxanes A and C (1 and 3) showed significant inhibitory activity in the syncytium reduction assay, with EC50 values of 55.2 and 27.5 μM, respectively.