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Complement-mediated muscle cell lysis: A possible mechanism of myonecrosis in anti-SRP associated necrotizing myopathy (ASANM)

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dc.contributor.authorArada Rojana-udomsarten_US
dc.contributor.authorChalermchai Mitrpanten_US
dc.contributor.authorChristine Bundellen_US
dc.contributor.authorLoren Priceen_US
dc.contributor.authorYue Bei Luoen_US
dc.contributor.authorVictoria Fabianen_US
dc.contributor.authorSteve D. Wiltonen_US
dc.contributor.authorPeter Hollingsworthen_US
dc.contributor.authorFrank L. Mastagliaen_US
dc.contributor.otherUniversity of Western Australiaen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherQueen Elizabeth II Medical Centre Trusten_US
dc.contributor.otherRoyal Perth Hospitalen_US
dc.date.accessioned2018-10-19T05:01:24Z
dc.date.available2018-10-19T05:01:24Z
dc.date.issued2013-09-16en_US
dc.description.abstractThe mechanism of necrotizing myopathy associated with antibodies to signal recognition particle (SRP) remains unclear. We investigated the effect of anti-SRP. +. serum and complement on cell viability in myoblast cultures. Cell viability was only slightly reduced by incubation with anti-SRP. +. serum compared with control serum. However, the addition of fresh complement resulted in a marked reduction in cell survival. Surface immunostaining for SRP, C3c and C5b-9 was demonstrated in cultures pre-incubated with anti-SRP. +. serum and complement, and in muscle biopsies from patients with myopathy. These findings provide further support for a complement-dependent antibody-mediated mechanism in anti-SRP associated myopathy. © 2013 Elsevier B.V.en_US
dc.identifier.citationJournal of Neuroimmunology. Vol.264, No.1-2 (2013), 65-70en_US
dc.identifier.doi10.1016/j.jneuroim.2013.08.008en_US
dc.identifier.issn18728421en_US
dc.identifier.issn01655728en_US
dc.identifier.other2-s2.0-84886773294en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/31869
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84886773294&origin=inwarden_US
dc.subjectImmunology and Microbiologyen_US
dc.subjectMedicineen_US
dc.subjectNeuroscienceen_US
dc.titleComplement-mediated muscle cell lysis: A possible mechanism of myonecrosis in anti-SRP associated necrotizing myopathy (ASANM)en_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84886773294&origin=inwarden_US

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