Publication: Resistance to the "last resort" antibiotic colistin: A single-zinc mechanism for phosphointermediate formation in MCR enzymes
2
Issued Date
2020-06-25
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ISSN
1364548X
13597345
13597345
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2-s2.0-85087096464
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Mahidol University
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SCOPUS
Bibliographic Citation
Chemical Communications. Vol.56, No.50 (2020), 6874-6877
Suggested Citation
Emily Lythell, Reynier Suardíaz, Philip Hinchliffe, Chonnikan Hanpaibool, Surawit Visitsatthawong, A. Sofia F. Oliveira, A. Sofia F. Oliveira, Eric J.M. Lang, Panida Surawatanawong, Vannajan Sanghiran Lee, Thanyada Rungrotmongkol, Natalie Fey, James Spencer, Adrian J. Mulholland Resistance to the "last resort" antibiotic colistin: A single-zinc mechanism for phosphointermediate formation in MCR enzymes. Chemical Communications. Vol.56, No.50 (2020), 6874-6877. doi:10.1039/d0cc02520h Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/57794
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Title
Resistance to the "last resort" antibiotic colistin: A single-zinc mechanism for phosphointermediate formation in MCR enzymes
Abstract
© 2020 The Royal Society of Chemistry. MCR (mobile colistin resistance) enzymes catalyse phosphoethanolamine (PEA) addition to bacterial lipid A, threatening the "last-resort"antibiotic colistin. Molecular dynamics and density functional theory simulations indicate that monozinc MCR supports PEA transfer to the Thr285 acceptor, positioning MCR as a mono-rather than multinuclear member of the alkaline phosphatase superfamily.