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Resistance to the "last resort" antibiotic colistin: A single-zinc mechanism for phosphointermediate formation in MCR enzymes

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dc.contributor.authorEmily Lythellen_US
dc.contributor.authorReynier Suardíazen_US
dc.contributor.authorPhilip Hinchliffeen_US
dc.contributor.authorChonnikan Hanpaiboolen_US
dc.contributor.authorSurawit Visitsatthawongen_US
dc.contributor.authorA. Sofia F. Oliveiraen_US
dc.contributor.authorA. Sofia F. Oliveiraen_US
dc.contributor.authorEric J.M. Langen_US
dc.contributor.authorPanida Surawatanawongen_US
dc.contributor.authorVannajan Sanghiran Leeen_US
dc.contributor.authorThanyada Rungrotmongkolen_US
dc.contributor.authorNatalie Feyen_US
dc.contributor.authorJames Spenceren_US
dc.contributor.authorAdrian J. Mulhollanden_US
dc.contributor.otherUniversity of Malayaen_US
dc.contributor.otherChulalongkorn Universityen_US
dc.contributor.otherUniversidad Complutense de Madriden_US
dc.contributor.otherUniversity of Portsmouthen_US
dc.contributor.otherUniversity of Bristolen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2020-08-25T09:23:38Z
dc.date.available2020-08-25T09:23:38Z
dc.date.issued2020-06-25en_US
dc.description.abstract© 2020 The Royal Society of Chemistry. MCR (mobile colistin resistance) enzymes catalyse phosphoethanolamine (PEA) addition to bacterial lipid A, threatening the "last-resort"antibiotic colistin. Molecular dynamics and density functional theory simulations indicate that monozinc MCR supports PEA transfer to the Thr285 acceptor, positioning MCR as a mono-rather than multinuclear member of the alkaline phosphatase superfamily.en_US
dc.identifier.citationChemical Communications. Vol.56, No.50 (2020), 6874-6877en_US
dc.identifier.doi10.1039/d0cc02520hen_US
dc.identifier.issn1364548Xen_US
dc.identifier.issn13597345en_US
dc.identifier.other2-s2.0-85087096464en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/57794
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85087096464&origin=inwarden_US
dc.subjectChemical Engineeringen_US
dc.subjectChemistryen_US
dc.subjectMaterials Scienceen_US
dc.titleResistance to the "last resort" antibiotic colistin: A single-zinc mechanism for phosphointermediate formation in MCR enzymesen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85087096464&origin=inwarden_US

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