Publication: Serum ferritin levels in children with dengue infection
Issued Date
2008-09-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-60249103662
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.39, No.5 (2008), 832-836
Suggested Citation
Wathanee Chaiyaratana, Ampaiwan Chuansumrit, Kalayanee Atamasirikul, Kanchana Tangnararatchakit Serum ferritin levels in children with dengue infection. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.39, No.5 (2008), 832-836. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/19553
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Serum ferritin levels in children with dengue infection
Other Contributor(s)
Abstract
The purpose of this study was to evaluate the levels of ferritin, an acute-phase reactant, in predicting the risk of dengue hemorrhagic fever (DHF) in patients with dengue infection. One hundred seventy-seven Thai children (100 males, 77 females) 4-16 years old (median age 11 years) with DF (n=44) and DHF (n=133) were enrolled in the study. All patients had serologic confirmation of dengue infection. Each had a venous blood sample drawn daily during hospitalization and at the outpatient clinic 2-4 weeks after discharge from the hospital,to determine serum ferritin levels. The median serum ferritin levels (ng/ml) in children with DHF (Day 2, 974; Day 3, 624; Day 4, 1,136; Day 5, 1,912; Day 6, 2,105; Day 7, 1,840; Day 8, 1,478 and Day 9, 1,144 of illness) were higher than those with DF (Day 2, 25.4; Day 3, 45.6; Day 4, 655; Day 5, 1,050; Day 6, 1,075; Day 7, 615; Day 8, 764 and Day 9, 600 of illness) with pvalues of 0.013, 0.001 and 0.013 on Days 5, 6 and 7 of illness, respectively. A cutoff level of serum ferritin of 1,200 ng/ml was used to calculate sensitivity and specificity for DHF. The results reveal the sensitivities on Days 5, 6 and 7 of illness were 81.5, 84.4 and 89.9%, respectively, and the specificities were 42.4, 39.0 and 36.4%, respectively. High serum ferritin levels ≥1,200 ng/ml may be a predictor of dengue hemorrhagic fever.