Publication: In vitro investigation of the protective effects of tannic acid against the activities of Naja kaouthia venom
Issued Date
2007-02-01
Resource Type
ISSN
17445116
13880209
13880209
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2-s2.0-33947227397
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Mahidol University
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SCOPUS
Bibliographic Citation
Pharmaceutical Biology. Vol.45, No.2 (2007), 94-97
Suggested Citation
Pimolpan Pithayanukul, Pakatip Ruenraroengsak, Rapepol Bavovada, Narumol Pakmanee, Rutt Suttisri In vitro investigation of the protective effects of tannic acid against the activities of Naja kaouthia venom. Pharmaceutical Biology. Vol.45, No.2 (2007), 94-97. doi:10.1080/13880200601112885 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24254
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Title
In vitro investigation of the protective effects of tannic acid against the activities of Naja kaouthia venom
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Abstract
The in vitro venom neutralizing capacity of tannic acid against the activities of Naja kaouthia (Naja naja kaouthia Lesson [Elapidae]) venom was investigated. Tannic acid was found to be effective in neutralizing the activities of Naja kaouthia (NK) venom. The lethal effect of four-times the LD50 in mice and the necrotizing effect of one minimum necrotizing dose (1 MND) in rats of NK venom were fully inhibited by tannic acid at ≥ 431 μg/mouse, with the median effective dose (ED50) of 334 μg/mouse and ≥ 30 μg/rat, respectively. The acetylcholinesterase activity of NK venom was almost completely neutralized (≥ 99%) by tannic acid at ≥ 1% w/v. It was evident that tannic acid was nontoxic and did not cause either a lethal effect in mice (at its maximum tested dose of 845 μg/mouse) or necrotic lesions in rats (at doses between 7.5 and 60 μg/rat). © 2007 Informa Healthcare.