Publication: In vitro investigation of the protective effects of tannic acid against the activities of Naja kaouthia venom
| dc.contributor.author | Pimolpan Pithayanukul | en_US |
| dc.contributor.author | Pakatip Ruenraroengsak | en_US |
| dc.contributor.author | Rapepol Bavovada | en_US |
| dc.contributor.author | Narumol Pakmanee | en_US |
| dc.contributor.author | Rutt Suttisri | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | Chulalongkorn University | en_US |
| dc.contributor.other | Thai Red Cross Agency | en_US |
| dc.date.accessioned | 2018-08-24T01:43:28Z | |
| dc.date.available | 2018-08-24T01:43:28Z | |
| dc.date.issued | 2007-02-01 | en_US |
| dc.description.abstract | The in vitro venom neutralizing capacity of tannic acid against the activities of Naja kaouthia (Naja naja kaouthia Lesson [Elapidae]) venom was investigated. Tannic acid was found to be effective in neutralizing the activities of Naja kaouthia (NK) venom. The lethal effect of four-times the LD50 in mice and the necrotizing effect of one minimum necrotizing dose (1 MND) in rats of NK venom were fully inhibited by tannic acid at ≥ 431 μg/mouse, with the median effective dose (ED50) of 334 μg/mouse and ≥ 30 μg/rat, respectively. The acetylcholinesterase activity of NK venom was almost completely neutralized (≥ 99%) by tannic acid at ≥ 1% w/v. It was evident that tannic acid was nontoxic and did not cause either a lethal effect in mice (at its maximum tested dose of 845 μg/mouse) or necrotic lesions in rats (at doses between 7.5 and 60 μg/rat). © 2007 Informa Healthcare. | en_US |
| dc.identifier.citation | Pharmaceutical Biology. Vol.45, No.2 (2007), 94-97 | en_US |
| dc.identifier.doi | 10.1080/13880200601112885 | en_US |
| dc.identifier.issn | 17445116 | en_US |
| dc.identifier.issn | 13880209 | en_US |
| dc.identifier.other | 2-s2.0-33947227397 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/24254 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33947227397&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.subject | Medicine | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | In vitro investigation of the protective effects of tannic acid against the activities of Naja kaouthia venom | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33947227397&origin=inward | en_US |