Publication:
Unstable vancomycin heteroresistance is common among clinical isolates of methiciliin-resistant Staphylococcus aureus

Issued Date

2005-05-01

Resource Type

Article

ISSN

00951137

DOI

10.1128/JCM.43.5.2494-2496.2005

Other identifier(s)

2-s2.0-18544374025

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of Clinical Microbiology. Vol.43, No.5 (2005), 2494-2496

Suggested Citation

Nottasorn Plipat, Gilat Livni, Heidi Bertram, Richard B. Thomson Unstable vancomycin heteroresistance is common among clinical isolates of methiciliin-resistant Staphylococcus aureus. Journal of Clinical Microbiology. Vol.43, No.5 (2005), 2494-2496. doi:10.1128/JCM.43.5.2494-2496.2005 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/16994

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Title

Unstable vancomycin heteroresistance is common among clinical isolates of methiciliin-resistant Staphylococcus aureus

Author(s)

Nottasorn Plipat
 Gilat Livni
 Heidi Bertram
 Richard B. Thomson

Other Contributor(s)

Mahidol University
 Schneider Childrens Medical Center Israel
 Department of Pathology and Laboratory Medicine
 Northwestern University Feinberg School of Medicine

Abstract

We tested 109 unique, vancomycin-susceptible, methicillin-resistant Staphylococcus aureus (MRSA) strains for vancomycin heteroresistance by a selection method, i.e., step-wise exposure of large inoculums to increasing concentrations of vancomycin. Although no strains demonstrated stable heteroresistance, 81 strains (74%) demonstrated unstable heteroresistance. Unstable heteroresistance is common among clinical isolates of MRSA and may represent a cause of therapeutic failure. Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/16994

Collections

Scopus 2001-2005