Publication: Chitosan Polymeric Micelles for Prevention of Cisplatin-Induced Nephrotoxicity and Anticancer Activity of Cisplatin
Issued Date
2020-09-15
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2-s2.0-85088159390
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Mahidol University
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SCOPUS
Bibliographic Citation
ACM International Conference Proceeding Series. (2020), 197-201
Suggested Citation
Sirima Soodvilai, Sunhapas Soodvilai, Warayuth Sajomsang, Theerasak Rojanarata, Prasopchai Patrojanasophon, Praneet Opanasopit Chitosan Polymeric Micelles for Prevention of Cisplatin-Induced Nephrotoxicity and Anticancer Activity of Cisplatin. ACM International Conference Proceeding Series. (2020), 197-201. doi:10.1145/3397391.3397438 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/57818
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Title
Chitosan Polymeric Micelles for Prevention of Cisplatin-Induced Nephrotoxicity and Anticancer Activity of Cisplatin
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Abstract
© 2020 ACM. This research aimed to determine the influence of chitosan derivatives, N-octyl-N,O-succinyl chitosan (OSCS), on prevention of cisplatin-induced nephrotoxicity and anticancer activity of cisplatin. The OSCS blank micelles was prepared by a dialysis approach. The OSCS polymeric micelles were successfully complexed with cisplatin. Cisplatin treatment significantly increased apoptotic cells compared with control. OSCS micelles were able to protect the cells against cisplatin-induced cytotoxicity. The result revealed that OSCS micelles decreased the nephrotoxicity without reversing activity of cisplatin in cancer cells. In addition, cisplatin-OSCS complex showed less toxicity in renal proximal tubular cells than cisplatin alone. Its anti-cancer activity was favorable but less potent than cisplatin alone. In conclusion, the present study demonstrates that the chitosan derivative, OSCS, might be developed as nephroprotective agent for cisplatin treatment.