Chitosan Polymeric Micelles for Prevention of Cisplatin-Induced Nephrotoxicity and Anticancer Activity of Cisplatin

Abstract

© 2020 ACM. This research aimed to determine the influence of chitosan derivatives, N-octyl-N,O-succinyl chitosan (OSCS), on prevention of cisplatin-induced nephrotoxicity and anticancer activity of cisplatin. The OSCS blank micelles was prepared by a dialysis approach. The OSCS polymeric micelles were successfully complexed with cisplatin. Cisplatin treatment significantly increased apoptotic cells compared with control. OSCS micelles were able to protect the cells against cisplatin-induced cytotoxicity. The result revealed that OSCS micelles decreased the nephrotoxicity without reversing activity of cisplatin in cancer cells. In addition, cisplatin-OSCS complex showed less toxicity in renal proximal tubular cells than cisplatin alone. Its anti-cancer activity was favorable but less potent than cisplatin alone. In conclusion, the present study demonstrates that the chitosan derivative, OSCS, might be developed as nephroprotective agent for cisplatin treatment.