Publication:
K13-Mediated Reduced Susceptibility to Artemisinin in Plasmodium falciparum Is Overlaid on a Trait of Enhanced DNA Damage Repair

Issued Date

2020-08-04

Resource Type

Article

ISSN

22111247

DOI

10.1016/j.celrep.2020.107996

Other identifier(s)

2-s2.0-85088856605

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Cell Reports. Vol.32, No.5 (2020)

Suggested Citation

Aoli Xiong, Prem Prakash, Xiaohong Gao, Marvin Chew, Ian Jun Jie Tay, Charles J. Woodrow, Bevin P. Engelward, Jongyoon Han, Peter R. Preiser K13-Mediated Reduced Susceptibility to Artemisinin in Plasmodium falciparum Is Overlaid on a Trait of Enhanced DNA Damage Repair. Cell Reports. Vol.32, No.5 (2020). doi:10.1016/j.celrep.2020.107996 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/57689

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Title

K13-Mediated Reduced Susceptibility to Artemisinin in Plasmodium falciparum Is Overlaid on a Trait of Enhanced DNA Damage Repair

Author(s)

Aoli Xiong
 Prem Prakash
 Xiaohong Gao
 Marvin Chew
 Ian Jun Jie Tay
 Charles J. Woodrow
 Bevin P. Engelward
 Jongyoon Han
 Peter R. Preiser

Other Contributor(s)

Singapore-MIT Alliance for Research and Technology
 School of Biological Sciences
 Massachusetts Institute of Technology
 Mahidol University

Abstract

© 2020 The Author(s) Southeast Asia (SEA) has been the breeding ground for malaria drug resistance, including resistance to artemisinin, the first-line anti-malarial drug. In this study, Xiong et al. find a relationship between DNA damage repair and artemisinin resistance in SEA, leading to insights on the establishment and spread of current artemisinin resistance.

Keyword(s)

Biochemistry, Genetics and Molecular Biology

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/57689

Collections

Scopus 2020