Publication: Metal-Free Direct C–H Thiolation and Thiocyanation of Pyrazolones
Issued Date
2020-02-28
Resource Type
ISSN
10990690
1434193X
1434193X
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2-s2.0-85079150929
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Mahidol University
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SCOPUS
Bibliographic Citation
European Journal of Organic Chemistry. Vol.2020, No.8 (2020), 961-970
Suggested Citation
Tanakorn Kittikool, Sirilata Yotphan Metal-Free Direct C–H Thiolation and Thiocyanation of Pyrazolones. European Journal of Organic Chemistry. Vol.2020, No.8 (2020), 961-970. doi:10.1002/ejoc.201901770 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/53640
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Title
Metal-Free Direct C–H Thiolation and Thiocyanation of Pyrazolones
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Abstract
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Metal-free approach for direct C–H thiolation and thiocyanation of N-substituted pyrazolones with disulfides and thiocyanate salts, respectively, are developed. These reactions allow the C–S bond coupling to proceed effectively under mild conditions, providing useful and convenient methods for preparation of a series of 4-thio-substituted pyrazolone analogues, which have potential applications in organic, medicinal and material chemistry. Preliminary mechanistic investigation suggested that radical processes are likely to involve in these transformations.