Publication: Mutational analysis of ras gene family in lung cancer in Thai
Issued Date
2003-09-01
Resource Type
ISSN
17912431
1021335X
1021335X
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2-s2.0-2142686614
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Mahidol University
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SCOPUS
Bibliographic Citation
Oncology Reports. Vol.10, No.5 (2003), 1497-1501
Suggested Citation
Songsak Petmitr, Duangdao Wongsommart, Panee Chaksangchaichot, Tanett Pakeetoot, Pantap Sutinont, Patay Sirivaidyapong, Anant Karalak Mutational analysis of ras gene family in lung cancer in Thai. Oncology Reports. Vol.10, No.5 (2003), 1497-1501. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20696
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Title
Mutational analysis of ras gene family in lung cancer in Thai
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Abstract
H-, K- and N-ras gene mutations were analyzed in lung cancer from Thai patients. Thirteen out of 58 cases (22%) harbored the mutations. Ten cases showed K-ras gene mutations at codon 12, 1 case presented a mutation at codon 13 and another case exhibited a mutation at codon 63. Silent mutations of N-ras gene in codons 57 and 62 were seen in one patient, whilst no H-ras mutation was found in these patients. Bases change in K-ras gene were G→T transversion (62%), G→A transition (15%) and G→C transition (15%), whereas T→G transversion and A→G transition were detected in N-ras mutant gene.