Mutational analysis of ras gene family in lung cancer in Thai

Abstract

H-, K- and N-ras gene mutations were analyzed in lung cancer from Thai patients. Thirteen out of 58 cases (22%) harbored the mutations. Ten cases showed K-ras gene mutations at codon 12, 1 case presented a mutation at codon 13 and another case exhibited a mutation at codon 63. Silent mutations of N-ras gene in codons 57 and 62 were seen in one patient, whilst no H-ras mutation was found in these patients. Bases change in K-ras gene were G→T transversion (62%), G→A transition (15%) and G→C transition (15%), whereas T→G transversion and A→G transition were detected in N-ras mutant gene.