Publication:
Synthesis of ethyl 5-phenyl-6-oxa-1-azabicyclo[3.1.0]hexane-2-carboxylate Derivatives and evaluation of their antimalarial activities

2

Issued Date

2003-06-05

Resource Type

Article

ISSN

00222623

DOI

10.1021/jm020452h

Other identifier(s)

2-s2.0-0038101387

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of Medicinal Chemistry. Vol.46, No.12 (2003), 2397-2403

Suggested Citation

Nongpanga Ningsanont, David St C Black, Rachada Chanphen, Yodhathai Thebtaranonth Synthesis of ethyl 5-phenyl-6-oxa-1-azabicyclo[3.1.0]hexane-2-carboxylate Derivatives and evaluation of their antimalarial activities. Journal of Medicinal Chemistry. Vol.46, No.12 (2003), 2397-2403. doi:10.1021/jm020452h Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/20720

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Title

Synthesis of ethyl 5-phenyl-6-oxa-1-azabicyclo[3.1.0]hexane-2-carboxylate Derivatives and evaluation of their antimalarial activities

Author(s)

Nongpanga Ningsanont
 David St C Black
 Rachada Chanphen
 Yodhathai Thebtaranonth

Other Contributor(s)

Mahidol University
 University of New South Wales (UNSW) Australia
 Thailand National Center for Genetic Engineering and Biotechnology

Abstract

Derivatives of ethyl 5-phenyl-6-oxa-1-azabicyclo[3.1.0]hexane-2-carboxylate (14-20), with side chains varying from three to five carbon atoms and bearing various substituents, have been prepared from ethyl 2-phenyl-1-pyrroline-5-carboxylate (12). Their in vitro activity against P. falciparum (K1 strain) and antimycobacterium and also their cytotoxic activity against Vero cell have been evaluated.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Pharmacology, Toxicology and Pharmaceutics

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URI

https://repository.li.mahidol.ac.th/handle/123456789/20720

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Scopus 2001-2005