Journal of Medicinal Chemistry. Vol.46, No.12 (2003), 2397-2403
Suggested Citation
Nongpanga Ningsanont, David St C Black, Rachada Chanphen, Yodhathai Thebtaranonth Synthesis of ethyl 5-phenyl-6-oxa-1-azabicyclo[3.1.0]hexane-2-carboxylate Derivatives and evaluation of their antimalarial activities. Journal of Medicinal Chemistry. Vol.46, No.12 (2003), 2397-2403. doi:10.1021/jm020452h Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20720
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Synthesis of ethyl 5-phenyl-6-oxa-1-azabicyclo[3.1.0]hexane-2-carboxylate Derivatives and evaluation of their antimalarial activities
Derivatives of ethyl 5-phenyl-6-oxa-1-azabicyclo[3.1.0]hexane-2-carboxylate (14-20), with side chains varying from three to five carbon atoms and bearing various substituents, have been prepared from ethyl 2-phenyl-1-pyrroline-5-carboxylate (12). Their in vitro activity against P. falciparum (K1 strain) and antimycobacterium and also their cytotoxic activity against Vero cell have been evaluated.
