Publication: Antimalarial activity of ferrocenyl chalcones
Issued Date
2002-09-02
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ISSN
0960894X
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2-s2.0-0037009255
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Mahidol University
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SCOPUS
Bibliographic Citation
Bioorganic and Medicinal Chemistry Letters. Vol.12, No.17 (2002), 2299-2302
Suggested Citation
Xiang Wu, Prapon Wilairat, Mei Lin Go Antimalarial activity of ferrocenyl chalcones. Bioorganic and Medicinal Chemistry Letters. Vol.12, No.17 (2002), 2299-2302. doi:10.1016/S0960-894X(02)00430-4 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20045
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Title
Antimalarial activity of ferrocenyl chalcones
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Abstract
A series of ferrocenyl chalcones were synthesized and evaluated for in vitro antimalarial activity against a chloroquine-resistant strain of Plasmodium falciparum. The most active compounds were 1-(3-pyridyl)-3-ferrocenyl-2-propen-1-one (6) and 1-ferrocenyl-3-(4-nitrophenyl)-2-propen-1-one (28) with IC50of 4.5 and 5.1 μM, respectively. Differences in activity were not readily explained by the size and lipophilicity characteristics of these compounds. © 2002 Elsevier Science Ltd. All rights reserved.