Publication: Antimalarial activity of ferrocenyl chalcones
| dc.contributor.author | Xiang Wu | en_US |
| dc.contributor.author | Prapon Wilairat | en_US |
| dc.contributor.author | Mei Lin Go | en_US |
| dc.contributor.other | National University of Singapore | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.date.accessioned | 2018-07-24T02:56:31Z | |
| dc.date.available | 2018-07-24T02:56:31Z | |
| dc.date.issued | 2002-09-02 | en_US |
| dc.description.abstract | A series of ferrocenyl chalcones were synthesized and evaluated for in vitro antimalarial activity against a chloroquine-resistant strain of Plasmodium falciparum. The most active compounds were 1-(3-pyridyl)-3-ferrocenyl-2-propen-1-one (6) and 1-ferrocenyl-3-(4-nitrophenyl)-2-propen-1-one (28) with IC50of 4.5 and 5.1 μM, respectively. Differences in activity were not readily explained by the size and lipophilicity characteristics of these compounds. © 2002 Elsevier Science Ltd. All rights reserved. | en_US |
| dc.identifier.citation | Bioorganic and Medicinal Chemistry Letters. Vol.12, No.17 (2002), 2299-2302 | en_US |
| dc.identifier.doi | 10.1016/S0960-894X(02)00430-4 | en_US |
| dc.identifier.issn | 0960894X | en_US |
| dc.identifier.other | 2-s2.0-0037009255 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/20045 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0037009255&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.subject | Chemistry | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | Antimalarial activity of ferrocenyl chalcones | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0037009255&origin=inward | en_US |