Publication: Small intestinal bacterial overgrowth and nonalcoholic fatty liver disease: A systematic review and meta-analysis
Issued Date
2020-01-01
Resource Type
ISSN
14735687
0954691X
0954691X
Other identifier(s)
2-s2.0-85083041330
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
European Journal of Gastroenterology and Hepatology. (2020), 601-608
Suggested Citation
Karn Wijarnpreecha, Susan Lou, Kanramon Watthanasuntorn, Paul T. Kroner, Wisit Cheungpasitporn, Frank J. Lukens, Surakit Pungpapong, Andrew P. Keaveny, Patompong Ungprasert Small intestinal bacterial overgrowth and nonalcoholic fatty liver disease: A systematic review and meta-analysis. European Journal of Gastroenterology and Hepatology. (2020), 601-608. doi:10.1097/MEG.0000000000001541 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/54681
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Title
Small intestinal bacterial overgrowth and nonalcoholic fatty liver disease: A systematic review and meta-analysis
Abstract
Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved. Objectives Recent studies have suggested that small intestinal bacterial overgrowth (SIBO) could be a predisposing factor for nonalcoholic fatty liver disease (NAFLD) although the results were inconsistent. This systematic review and meta-analysis was conducted with the aim to summarize all available data. Methods A comprehensive literature review was conducted utilizing MEDLINE and EMBASE databases through September 2018 to identify all studies that compared the risk of NAFLD among patients with SIBO versus those without SIBO. Effect estimates from each study were extracted and combined together using the random effect, generic inverse variance method of DerSimonian and Laird. Results A total of 10 studies with 1093 participants fulfilled the eligibility criteria and were included in the meta-analysis. A significant association between NAFLD and SIBO was observed with the pooled odds ratio of 3.82 (95% confidence interval, 1.93–7.59; I2 65%). Funnel plot is relatively symmetric and is not suggestive of the presence of publication bias. Conclusion A significant association between NAFLD and SIBO was observed in this meta-analysis.