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Small intestinal bacterial overgrowth and nonalcoholic fatty liver disease: A systematic review and meta-analysis

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dc.contributor.authorKarn Wijarnpreechaen_US
dc.contributor.authorSusan Louen_US
dc.contributor.authorKanramon Watthanasuntornen_US
dc.contributor.authorPaul T. Kroneren_US
dc.contributor.authorWisit Cheungpasitpornen_US
dc.contributor.authorFrank J. Lukensen_US
dc.contributor.authorSurakit Pungpapongen_US
dc.contributor.authorAndrew P. Keavenyen_US
dc.contributor.authorPatompong Ungpraserten_US
dc.contributor.otherUniversity of Minnesotaen_US
dc.contributor.otherFaculty of Medicine, Siriraj Hospital, Mahidol Universityen_US
dc.contributor.otherUniversity of Mississippi Medical Centeren_US
dc.contributor.otherThe Mary Imogene Bassett Hospitalen_US
dc.contributor.otherMayo Clinic in Jacksonville, Floridaen_US
dc.date.accessioned2020-05-05T05:56:56Z
dc.date.available2020-05-05T05:56:56Z
dc.date.issued2020-01-01en_US
dc.description.abstractCopyright © 2019 Wolters Kluwer Health, Inc. All rights reserved. Objectives Recent studies have suggested that small intestinal bacterial overgrowth (SIBO) could be a predisposing factor for nonalcoholic fatty liver disease (NAFLD) although the results were inconsistent. This systematic review and meta-analysis was conducted with the aim to summarize all available data. Methods A comprehensive literature review was conducted utilizing MEDLINE and EMBASE databases through September 2018 to identify all studies that compared the risk of NAFLD among patients with SIBO versus those without SIBO. Effect estimates from each study were extracted and combined together using the random effect, generic inverse variance method of DerSimonian and Laird. Results A total of 10 studies with 1093 participants fulfilled the eligibility criteria and were included in the meta-analysis. A significant association between NAFLD and SIBO was observed with the pooled odds ratio of 3.82 (95% confidence interval, 1.93–7.59; I2 65%). Funnel plot is relatively symmetric and is not suggestive of the presence of publication bias. Conclusion A significant association between NAFLD and SIBO was observed in this meta-analysis.en_US
dc.identifier.citationEuropean Journal of Gastroenterology and Hepatology. (2020), 601-608en_US
dc.identifier.doi10.1097/MEG.0000000000001541en_US
dc.identifier.issn14735687en_US
dc.identifier.issn0954691Xen_US
dc.identifier.other2-s2.0-85083041330en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/54681
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85083041330&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleSmall intestinal bacterial overgrowth and nonalcoholic fatty liver disease: A systematic review and meta-analysisen_US
dc.typeReviewen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85083041330&origin=inwarden_US

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