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Cross-species transmission of gibbon and orangutan hepatitis B virus to uPA/SCID mice with human hepatocytes

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dc.contributor.authorPattaratida Sa-nguanmooen_US
dc.contributor.authorYasuhito Tanakaen_US
dc.contributor.authorParntep Ratanakornen_US
dc.contributor.authorMasaya Sugiyamaen_US
dc.contributor.authorShuko Murakamien_US
dc.contributor.authorSunchai Payungpornen_US
dc.contributor.authorAngkana Sommanustweechaien_US
dc.contributor.authorMasashi Mizokamien_US
dc.contributor.authorYong Poovorawanen_US
dc.contributor.otherChulalongkorn Universityen_US
dc.contributor.otherNagoya City University Graduate School of Medical Sciencesen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNational Center for Global Health and Medicineen_US
dc.contributor.otherZoological Park Organization, Bangkoken_US
dc.date.accessioned2018-05-03T08:02:35Z
dc.date.available2018-05-03T08:02:35Z
dc.date.issued2011-06-01en_US
dc.description.abstractTo investigate the potential of cross-species transmission of non-human primate HBV to humans, severe combined immunodeficiency mice transgenic for urokinase-type plasminogen activator, in which the mouse liver has been engrafted with human hepatocytes, were inoculated with non-human primate HBV. HBV-DNA positive serum samples from a gibbon or orangutan were inoculated into 6 chimeric mice. HBV-DNA, hepatitis B surface antigen (HBsAg), and HB core-related antigen in sera and HBV cccDNA in liver were detectable in 2 of 3 mice each from the gibbon and orangutan. Likewise, applying immunofluorescence HBV core protein was only found in human hepatocytes expressing human albumin. The HBV sequences from mouse sera were identical to those from orangutan and gibbon sera determined prior to inoculation. In conclusion, human hepatocytes have been infected with gibbon/orangutan HBV. © 2011 Elsevier B.V.en_US
dc.identifier.citationVirus Research. Vol.158, No.1-2 (2011), 209-215en_US
dc.identifier.doi10.1016/j.virusres.2011.04.002en_US
dc.identifier.issn18727492en_US
dc.identifier.issn01681702en_US
dc.identifier.other2-s2.0-79956305144en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/11547
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79956305144&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectImmunology and Microbiologyen_US
dc.subjectMedicineen_US
dc.titleCross-species transmission of gibbon and orangutan hepatitis B virus to uPA/SCID mice with human hepatocytesen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79956305144&origin=inwarden_US

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