Publication: Development of push-pull osmotic tablets using Chitosan-poly(acrylic acid) interpolymer complex as an osmopolymer
Issued Date
2011-03-01
Resource Type
ISSN
15309932
Other identifier(s)
2-s2.0-79954424462
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Mahidol University
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SCOPUS
Bibliographic Citation
AAPS PharmSciTech. Vol.12, No.1 (2011), 132-140
Suggested Citation
Wichan Ketjinda, Nuttanan Sinchaipanid, Pichet Limsuwan, Hans Leuenberger, Ampol Mitrevej Development of push-pull osmotic tablets using Chitosan-poly(acrylic acid) interpolymer complex as an osmopolymer. AAPS PharmSciTech. Vol.12, No.1 (2011), 132-140. doi:10.1208/s12249-010-9572-z Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/11350
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Title
Development of push-pull osmotic tablets using Chitosan-poly(acrylic acid) interpolymer complex as an osmopolymer
Abstract
The objectives of this study were to prepare push-pull osmotic tablets (PPOT) of felodipine using an interpolymer complex of chitosan (CS) and poly(acrylic acid) (PAA) as an osmopolymer, and to study the mechanisms of drug release from these tablets. The interpolymer complexes were prepared with different weight ratios of CS to PAA. Preparation of PPOT involved the fabrication of bilayered tablets with the drug layer, containing felodipine, polyethylene oxide, and the polymeric expansion layer, containing the CS-PAA complex. The effects of polymer ratios, type of plasticizers, and compression forces on release characteristics were investigated. It was found that drug release from PPOT exhibited zero-order kinetics and could be prolonged up to 12 or 24 h depending on the plasticizer used. PPOT using dibutyl sebacate showed a longer lag time and slower drug release than that using polyethylene glycol 400. In the case of polyethylene glycol 400, an increase in the CS proportion resulted in an increase in the drug release rate. The compression force had no effect on drug release from PPOT. Drug release was controlled by two consecutive mechanisms: an osmotic pump effect resulting in the extrusion of the drug layer from the tablet and subsequent erosion and dissolution of the extruded drug layer in the dissolution medium. The mathematical model (zero-order) related to extrusion and erosion rates for describing the mechanism of drug release showed a good correlation between predicted and observed values. © 2010 American Association of Pharmaceutical Scientists.